Do Not Use Alcohol or Other Solvents on Acrylic Shields The most important thing to understand before cleaning acrylic or plexiglass shields is to never use harmful solvents. Especially refrain from using alcohol such as methyl, ethyl, isopropanol, or acetone. Cleaning acrylic in this manner will lead to microfractures and cloudiness, compromising surface integrity. In short, using harsh solvents will …